Table_Type Family Family_Link Family_Note Family_Note_Link Family_Indicator Alt Alt_Note Alt_Note_Link Alt_Indicator AN AN_Link AN_Note AN_Note_Link AN_Indicator Name Name_Note Name_Note_Link Name_Indicator EC EC_Links EC_Note EC_Note_Link EC_Indicator Organism Organism_Note Organism_Note_Link Organism_Indicator Cell_Loc Cell_Loc_Note Cell_Loc_Note_Link Cell_Loc_Indicator AAs AAs_Note AAs_Note_Link AAs_Indicator Structure Structure_Note Structure_Note_Link Structure_Indicator PDB_IDs PDB_RCSB_Links PDB_UniProt_Links PDB_Note PDB_Indicator Km Km_DOIs Km_Note Km_Indicator Vmax Vmax_DOIs Vmax_Note Vmax_Indicator Kcat Kcat_DOIs Kcat_Note Kcat_Indicator ESP 1-1-1 /html-files/class1-family1.html - Sequence available in publication. No similar sequences could be found in databases. As presented, lacks the critical conserved Motif 1. i 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Cladosporium sp. - 370 - 100 https://doi.org/10.1007/s11274-012-1213-0 ESP 1-1-1 /html-files/class1-family1.html - A0A4D6C6W0 https://www.uniprot.org/uniprotkb/A0A4D6C6W0/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Cobetia amphilecti - 316 - 2.05 https://doi.org/10.1016/j.ijbiomac.2019.10.258 11641 https://doi.org/10.1016/j.ijbiomac.2019.10.258 ESP 1-1-1 /html-files/class1-family1.html - C5E3N2 https://www.uniprot.org/uniprotkb/C5E3N2/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Lachancea thermotolerans - 375 - 11.67 https://doi.org/10.1016/j.bej.2023.108806 312.45 https://doi.org/10.1016/j.bej.2023.108806 ESP 1-1-1 /html-files/class1-family1.html ScAII Identical sequences: P0CZ17, P0CX77, P0CX78, P0CX79 i P0CZ17 https://www.uniprot.org/uniprotkb/P0CZ17/entry ASP21_YEAST 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Saccharomyces cerevisiae Secreted 362 - 0.27 https://doi.org/10.1016/s0021-9258(17)38144-9  42 https://doi.org/10.1016/s0021-9258(17)38144-9  ESP 1-1-1 /html-files/class1-family1.html ScAI P38986 https://www.uniprot.org/uniprotkb/P38986/entry ASPG1_YEAST 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Saccharomyces cerevisiae Cytoplasm 381 - 0.075 https://doi.org/10.1038/srep36239 K_0.5, allosteric enzyme i ESP 1-1-3 /html-files/class1-family3.html - P10172 https://www.uniprot.org/uniprotkb/P10172/entry ASPQ_ACIGL 3.5.1.38 https://enzyme.expasy.org/EC/3.5.1.38 Acinetobacter glutaminasificans Periplasm 331 Homo tetramer 1AGX https://www.rcsb.org/structure/1AGX ESP 1-1-3 /html-files/class1-family3.html - Q5E4M4 https://www.uniprot.org/uniprotkb/Q5E4M4/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Aliivibrio fischeri - 353 - 1.2275 https://doi.org/10.1007/s00449-022-02769-x ESP 1-1-3 /html-files/class1-family3.html - UPI0002D9BB57 https://www.uniprot.org/uniparc/UPI0002D9BB57/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus altitudinis - 382 - 0.0147 https://doi.org/10.1093/jambio/lxae062 ESP 1-1-3 /html-files/class1-family3.html - A0A0P7GBY8 https://www.uniprot.org/uniprotkb/A0A0P7GBY8/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus australimaris - 382 - 0.0456 https://doi.org/10.1016/j.ijbiomac.2022.06.110 Sequence may not be exact match i 74.6 https://doi.org/10.1016/j.ijbiomac.2022.06.110 Sequence may not be exact match i ESP 1-1-3 /html-files/class1-family3.html - A0A2P8QZG9 https://www.uniprot.org/uniprotkb/A0A2P8QZG9/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Campylobacter blaseri - 347 - 1.91 https://doi.org/10.1016/j.bej.2023.108806 13.94 https://doi.org/10.1016/j.bej.2023.108806 ESP 1-1-3 /html-files/class1-family3.html - Q0PC96 https://www.uniprot.org/uniprotkb/Q0PC96/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Campylobacter jejuni - 331 Homo tetramer 3NXK https://www.rcsb.org/structure/3NXK ESP 1-1-3 /html-files/class1-family3.html ErA, type II P06608 https://www.uniprot.org/uniprotkb/P06608/entry ASPG_DICCH 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Dickeya chrysanthemi - 348 Homo tetramer 5F52 https://www.rcsb.org/structure/5F52 https://www.uniprot.org/uniprotkb/P06608/entry#structure 0.058 https://doi.org/10.1111/j.1742-4658.2009.06910.x Sequence may not be exact match i 565 https://doi.org/10.1007/s12033-014-9766-9 Sequence may not be exact match. K_cat may not correspond to K_m. i ESP 1-1-3 /html-files/class1-family3.html EcAII P00805 https://www.uniprot.org/uniprotkb/P00805/entry ASPG2_ECOLI 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Escherichia coli Periplasm 348 Homo tetramer 3ECA https://www.rcsb.org/structure/3eca https://www.uniprot.org/uniprotkb/P00805/entry#structure 0.015 https://doi.org/10.1110/ps.9.10.2009 24 https://doi.org/10.1110/ps.9.10.2009 ESP 1-1-3 /html-files/class1-family3.html - A0A4Q0YCX3 https://www.uniprot.org/uniprotkb/A0A4Q0YCX3/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Halarcobacter ebronensis - 349 - 4.27 https://doi.org/10.1016/j.bej.2023.108806 16.55 https://doi.org/10.1016/j.bej.2023.108806 ESP 1-1-3 /html-files/class1-family3.html HpA, type II Q9ZLB9 https://www.uniprot.org/uniprotkb/Q9ZLB9/entry ASPG_HELPJ 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) i Cytoplasm 332 Homo tetramer PDBs https://www.uniprot.org/uniprotkb/Q9ZLB9/entry#structure 0.29 https://doi.org/10.1371/journal.pone.0117025 S_0.5, Sequence may not be exact match i 31.22 https://doi.org/10.1371/journal.pone.0117025 Sequence may not be exact match i 19.26 https://doi.org/10.1371/journal.pone.0117025 Sequence may not be exact match i ESP 1-1-3 /html-files/class1-family3.html - UPI0010229EFA https://www.uniprot.org/uniparc/UPI0010229EFA/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Iodobacter sp. - 355 - 1.2 https://doi.org/10.1007/s11756-024-01624-6 82 https://doi.org/10.1007/s11756-024-01624-6 ESP 1-1-3 /html-files/class1-family3.html - I3DG54 https://www.uniprot.org/uniprotkb/I3DG54/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pasteurella bettyae - 349 - 3.98 https://doi.org/10.1016/j.bej.2023.108806 69.12 https://doi.org/10.1016/j.bej.2023.108806 ESP 1-1-3 /html-files/class1-family3.html - Q7WWK9 https://www.uniprot.org/uniprotkb/Q7WWK9/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pectobacterium atrosepticum (Erwinia carotovora subsp. atroseptica) i - 349 Homo tetramer 2HLN https://www.rcsb.org/structure/2HLN 0.098 https://doi.org/10.1042/BA20030138 732 https://doi.org/10.1042/BA20030138 1600 https://doi.org/10.1042/BA20030138 ESP 1-1-3 /html-files/class1-family3.html - P10182 https://www.uniprot.org/uniprotkb/P10182/entry ASPQ_PSES7 3.5.1.38 https://enzyme.expasy.org/EC/3.5.1.38 Pseudomonas sp. Periplasm 337 Homo tetramer 3PGA https://www.rcsb.org/structure/3PGA https://www.uniprot.org/uniprotkb/P10182/entry#structure ESP 1-1-3 /html-files/class1-family3.html - Exact sequence available in publication i 3.5.1.38 https://enzyme.expasy.org/EC/3.5.1.38 Pseudomonas sp. Himalayan Pseudomonas sp. PCH44 i - 366 - 0.56 https://doi.org/10.1007/s13205-022-03224-0 18.06 https://doi.org/10.1007/s13205-022-03224-0 ESP 1-1-3 /html-files/class1-family3.html - A0A3R9P3J0 https://www.uniprot.org/uniprotkb/A0A3R9P3J0/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Salibacterium salarium Bacillus salarius i - 359 - 5.59 https://doi.org/10.1016/j.bej.2023.108806 8.87 https://doi.org/10.1016/j.bej.2023.108806 ESP 1-1-3 /html-files/class1-family3.html - A0A0H2WSV5 https://www.uniprot.org/uniprotkb/A0A0H2WSV5/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Salmonella paratyphi - 348 - 28 https://doi.org/10.1016/j.ijbiomac.2024.135458 39.6 https://doi.org/10.1016/j.ijbiomac.2024.135458 ESP 1-1-3 /html-files/class1-family3.html - A0A240C149 https://www.uniprot.org/uniprotkb/A0A240C149/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Serratia ficaria - 349 - 1.42 https://doi.org/10.1016/j.bej.2023.108806 ESP 1-1-3 /html-files/class1-family3.html - A0A1D8KVW6 https://www.uniprot.org/uniprotkb/A0A1D8KVW6/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Serratia marcescens From soil metagenomic libraries generated from forest soil. Possibly Serratia marcescens (estimation). i - 348 - 2.0 https://doi.org/10.1007/s10529-017-2470-7 15.5 https://doi.org/10.1007/s10529-017-2470-7 ESP 1-1-3 /html-files/class1-family3.html - A0A2D3WDS0 https://www.uniprot.org/uniprotkb/A0A2D3WDS0/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Sulfurospirillum cavolei - 348 - 0.63 https://doi.org/10.1016/j.bej.2023.108806 10.14 https://doi.org/10.1016/j.bej.2023.108806 ESP 1-1-3 /html-files/class1-family3.html - D1B4K0 https://www.uniprot.org/uniprotkb/D1B4K0/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Sulfurospirillum deleyianum - 348 - 1.80 https://doi.org/10.1016/j.bej.2023.108806 20.16 https://doi.org/10.1016/j.bej.2023.108806 ESP 1-1-3 /html-files/class1-family3.html WsA, type II P50286 https://www.uniprot.org/uniprotkb/P50286/entry ASPG_WOLSU 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Wolinella succinogenes Cytoplasm 330 Homo tetramer 1WSA https://www.rcsb.org/structure/1WSA https://www.uniprot.org/uniprotkb/P50286/entry#structure 0.0217 https://doi.org/10.1038/srep41643 97.8 https://doi.org/10.1038/srep41643 ESP 1-1-3 /html-files/class1-family3.html - D3VBI4 https://www.uniprot.org/uniprotkb/D3VBI4/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Xenorhabdus nematophila - 347 - 4.27 https://doi.org/10.1016/j.bej.2023.108806 6.43 https://doi.org/10.1016/j.bej.2023.108806 ESP 1-1-3 /html-files/class1-family3.html - Q66CJ2 https://www.uniprot.org/uniprotkb/Q66CJ2/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Yersinia pseudotuberculosis - 345 - 0.017 https://doi.org/10.1016/j.pep.2011.12.005 ESP 1-2-5 /html-files/class1-family5.html - A0A3Q8UES2 https://www.uniprot.org/uniprotkb/A0A3Q8UES2/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus cereus - 325 Homo dimer Determined by gel filtration chromatography i 9.38 https://doi.org/10.1016/j.jbiosc.2018.09.007 63.6 https://doi.org/10.1016/j.jbiosc.2018.09.007 ESP 1-2-5 /html-files/class1-family5.html - Very similar sequence to ASPG_BACLI, but not identical i A0A6I7U6Y2 https://www.uniprot.org/uniprotkb/A0A6I7U6Y2/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus licheniformis - 322 Homo dimer 7CB4 https://www.rcsb.org/structure/7CB4 https://www.uniprot.org/uniprotkb/A0A6I7U6Y2/entry#structure 2.96 https://doi.org/10.1021/acs.jafc.2c05712 ESP 1-2-5 /html-files/class1-family5.html - Very similar sequence to ASPG_BACLI, but not identical i A0A3G1GZN5 https://www.uniprot.org/uniprotkb/A0A3G1GZN5/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus licheniformis - 322 - 0.0106 https://doi.org/10.15171/bi.2019.03 23.96 https://doi.org/10.15171/bi.2019.03 ESP 1-2-5 /html-files/class1-family5.html - Q5KXR8 https://www.uniprot.org/uniprotkb/Q5KXR8/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Geobacillus kaustophilus - 323 - 0.487 https://doi.org/10.1016/j.pep.2022.106146 243.9 https://doi.org/10.1016/j.pep.2022.106146 ESP 1-2-5 /html-files/class1-family5.html - A0A7U9P5Z0 https://www.uniprot.org/uniprotkb/A0A7U9P5Z0/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Geobacillus thermopakistaniensis - 323 - Biochemical characterization revealed that ASNaseGt existed in an oligomeric form in solution which can be converted to the most active tetrameric form by the addition of thiol reducers. i 0.35 https://doi.org/10.1016/j.ijbiomac.2024.130438 2735 https://doi.org/10.1016/j.ijbiomac.2024.130438 1595 https://doi.org/10.1016/j.ijbiomac.2024.130438 ESP 1-2-5 /html-files/class1-family5.html - F0TGT0 https://www.uniprot.org/uniprotkb/F0TGT0/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Lactobacillus acidophilus - 331 - 6.23 https://doi.org/10.26502/jbb.2642-91280015 0.51 https://doi.org/10.26502/jbb.2642-91280015 ESP 1-2-5 /html-files/class1-family5.html - A0AAD1ETD3 https://www.uniprot.org/uniprotkb/A0AAD1ETD3/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Lactobacillus casei - 324 - 0.0123 https://doi.org/10.1007/s12088-019-00806-0 Sequence may not be exact match i ESP 1-2-5 /html-files/class1-family5.html - F9URL2 https://www.uniprot.org/uniprotkb/F9URL2/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Lactobacillus plantarum - 324 - 7.85 https://doi.org/10.26502/jbb.2642-91280015 2.33 https://doi.org/10.26502/jbb.2642-91280015 ESP 1-2-5 /html-files/class1-family5.html - Q38YS9 https://www.uniprot.org/uniprotkb/Q38YS9/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Latilactobacillus sakei - 324 Homo dimer Determined by gel filtration i 7.64 https://doi.org/10.26502/jbb.2642-91280015 4.09 https://doi.org/10.26502/jbb.2642-91280015 ESP 1-2-5 /html-files/class1-family5.html - I6ZQC6 https://www.uniprot.org/uniprotkb/I6ZQC6/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Melioribacter roseus - 326 - 2.7 https://doi.org/10.3390/catal13050832 163 https://doi.org/10.3390/catal13050832 96 https://doi.org/10.3390/catal13050832 ESP 1-2-5 /html-files/class1-family5.html - brenda-enzymes.org, archived id J9H7D1 i A0A9X4QZ02 https://www.uniprot.org/uniprotkb/A0A9X4QZ02/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Staphylococcus sp. - 324 Homo dimer Size-exclusion chromatography determined i 2.2 https://doi.org/10.4014/jmb.1405.05021 4.65 https://doi.org/10.4014/jmb.1405.05021 ESP 1-2-5 /html-files/class1-family5.html - A0A062WR39 https://www.uniprot.org/uniprotkb/A0A062WR39/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Streptococcus pneumoniae - 320 Monomer Context unknown, paper to be published i 9D91 https://www.rcsb.org/structure/9D91 Paper to be published i ESP 1-2-5 /html-files/class1-family5.html - Q5M2S9 https://www.uniprot.org/uniprotkb/Q5M2S9/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Streptococcus thermophilus - 322 - 2.34 https://doi.org/10.26502/jbb.2642-91280015 101 https://doi.org/10.26502/jbb.2642-91280015 ESP 1-2-6 /html-files/class1-family6.html - A0A1X1VDM8 https://www.uniprot.org/uniprotkb/A0A1X1VDM8/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Mycobacterium gordonae - 312 - 6.025 https://doi.org/10.3390/foods10112819 194.8 https://doi.org/10.3390/foods10112819 ESP 1-2-6 /html-files/class1-family6.html - A0QX50 https://www.uniprot.org/uniprotkb/A0QX50/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Mycobacterium smegmatis - 320 - 1.403 https://doi.org/10.1021/acsomega.4c06459 708.1 https://doi.org/10.1021/acsomega.4c06459 ESP 1-2-6 /html-files/class1-family6.html - P9WPX5 https://www.uniprot.org/uniprotkb/P9WPX5/entry ASPG_MYCTU 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), identical to P9WPX4 i Secreted 315 Dimer 0.38 8.3 19.57 https://doi.org/10.1016/j.biochi.2020.12.023 74.08 797.7 1587.7 https://doi.org/10.1016/j.biochi.2020.12.023 80.7 869.4 1732.5 https://doi.org/10.1016/j.biochi.2020.12.023 ESP 1-4-10 /html-files/class1-family10.html - Q2RMX1 https://www.uniprot.org/uniprotkb/Q2RMX1/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Rhodospirillum rubrum - 172 Homo tetramer Specific tetrameric structure, as this family lacks the C-terminal stabilizing domain present in the other Class 1 families i 8UOO https://www.rcsb.org/structure/8UOO https://www.uniprot.org/uniprotkb/Q2RMX1/entry#structure 2.9;3.6;0.280 https://doi.org/10.1002/pro.4920;https://doi.org/10.1002/pro.4920;https://doi.org/10.1007/s12033-014-9819-0 Later results indicate a millimolar Km i 57.1;58.2 https://doi.org/10.1002/pro.4920;https://doi.org/10.1002/pro.4920 ESP 1-4-11 /html-files/class1-family11.html - R4L284 https://www.uniprot.org/uniprotkb/R4L284/entry Uncertain if sequence and kinetics data match. As presented, the protein lacks the critical conserved Motif 1. ! 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus licheniformis - 272 - 0.671 https://doi.org/10.1007/s12010-014-1200-z As presented, the protein lacks the critical conserved Motif 1 ! 36.8 https://doi.org/10.1007/s12010-014-1200-z As presented, the protein lacks the critical conserved Motif 1 ! ESP 1-4-11 /html-files/class1-family11.html - A0A6G7ABJ6 https://www.uniprot.org/uniprotkb/A0A6G7ABJ6/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus sonorensis - 329 - 2.004 https://doi.org/10.1007/s10930-020-09932-x ESP 1-4-11 /html-files/class1-family11.html - P26900 https://www.uniprot.org/uniprotkb/P26900/entry ASPG1_BACSU 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus subtilis Cytoplasm 329 - 1.579 https://doi.org/10.1007/s10123-024-00493-y Sequence may not be exact match i ESP 1-4-11 /html-files/class1-family11.html - A0A291B5A4 https://www.uniprot.org/uniprotkb/A0A291B5A4/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus tequilensis - 329 - 0.070 https://doi.org/10.1038/s41598-018-36161-1 ESP 1-4-11 /html-files/class1-family11.html - A5VMR3 https://www.uniprot.org/uniprotkb/A5VMR3/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Lactobacillus reuteri - 329 - 0.3332 https://doi.org/10.1007/s13205-017-0974-4 Sequence may not be exact match i ESP 1-4-11 /html-files/class1-family11.html - A0A0R2I8I9 https://www.uniprot.org/uniprotkb/A0A0R2I8I9/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Limosilactobacillus secaliphilus - 333 - 4.78 https://doi.org/10.1007/s12010-023-04715-3 887 https://doi.org/10.1007/s12010-023-04715-3 ESP 1-4-11 /html-files/class1-family11.html - Q8TZE8 https://www.uniprot.org/uniprotkb/Q8TZE8/entry ASPG_PYRFU 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pyrococcus furiosus - 326 Homo dimer / tetramer Temperature dependent i 5CBP https://www.rcsb.org/structure/5CBP https://www.uniprot.org/uniprotkb/Q8TZE8/entry#structure 12 https://doi.org/10.1134/s0006297910030144 870 https://doi.org/10.1134/s0006297910030144 ESP 1-4-11 /html-files/class1-family11.html PhA O57797 https://www.uniprot.org/uniprotkb/O57797/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pyrococcus horikoshii - 328 Homo dimer 1WLS https://www.rcsb.org/structure/1WLS https://www.uniprot.org/uniprotkb/O57797/entry#structure ESP 1-4-11 /html-files/class1-family11.html - F8AHM4 https://www.uniprot.org/uniprotkb/F8AHM4/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pyrococcus yayanosii - 328 - 6.5 https://doi.org/10.1007/s00253-019-09967-w ESP 1-4-11 /html-files/class1-family11.html - C5A6T2 https://www.uniprot.org/uniprotkb/C5A6T2/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Thermococcus gammatolerans - 328 - 5.3 https://doi.org/10.1007/s00253-019-09967-w ESP 1-4-11 /html-files/class1-family11.html - Q5JIW4 https://www.uniprot.org/uniprotkb/Q5JIW4/entry ASPG_THEKO 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Thermococcus kodakarensis - 328 Homo dimer 5OT0 https://www.rcsb.org/structure/5OT0 2.6;5.5 https://doi.org/10.1002/jobm.201300741;https://doi.org/10.1016/j.jbiosc.2013.04.005 1121;3300 https://doi.org/10.1002/jobm.201300741;https://doi.org/10.1016/j.jbiosc.2013.04.005 694 https://doi.org/10.1002/jobm.201300741 ESP 1-4-11 /html-files/class1-family11.html - C6A532 https://www.uniprot.org/uniprotkb/C6A532/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Thermococcus sibiricus - 331 - 4.7 https://doi.org/10.3390/catal13050832 640 https://doi.org/10.3390/catal13050832 400 https://doi.org/10.3390/catal13050832 ESP 1-4-11 /html-files/class1-family11.html - UPI00029ABCE1 https://www.uniprot.org/uniparc/UPI00029ABCE1/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Thermococcus zilligii - 330 - 6.08 https://doi.org/10.1007/s00792-015-0763-0 3267 https://doi.org/10.1007/s00792-015-0763-0 ESP 1-4-12 /html-files/class1-family12.html - O26802 https://www.uniprot.org/uniprotkb/O26802/entry GATD_METTH 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanothermobacter thermautotrophicus - 435 Hetero tetramer Has additional domain. i 2D6F https://www.rcsb.org/structure/2D6F ESP 1-4-12 /html-files/class1-family12.html - Q9V0T9 https://www.uniprot.org/uniprotkb/Q9V0T9/entry GATD_PYRAB 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Pyrococcus abyssi - 438 Hetero tetramer Has additional domain. i 1ZQ1 https://www.rcsb.org/structure/1ZQ1 ESP 1-5-14 /html-files/class1-family14.html CpAI H0W0T5 https://www.uniprot.org/uniprotkb/H0W0T5/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Cavia porcellus - 565 Homo tetramer Additional ankyrin repeats. i 4R8L https://www.rcsb.org/structure/4R8L https://www.uniprot.org/uniprotkb/H0W0T5/entry#structure 0.057 https://doi.org/10.1074/jbc.M114.609552 38.6 https://doi.org/10.1074/jbc.M114.609552 ESP 1-5-14 /html-files/class1-family14.html hAI Q86U10 https://www.uniprot.org/uniprotkb/Q86U10/entry LPP60_HUMAN 3.1.1.5;3.5.1.1;3.1.1.47 https://enzyme.expasy.org/EC/3.1.1.5;https://enzyme.expasy.org/EC/3.5.1.1;https://enzyme.expasy.org/EC/3.5.1.47 Homo sapiens - 573 Monomer At assay conditions, substrate-inducing effect on the oligomeric state i 11.5 https://www.jbc.org/article/S0021-9258(20)38784-6/fulltext S_0.5, allosteric enzyme i 6.7 https://www.jbc.org/article/S0021-9258(20)38784-6/fulltext ESP 1-5-15 /html-files/class1-family15.html RmAI W0G253 https://www.uniprot.org/uniprotkb/W0G253/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Rhizomucor miehei - 682 Homo dimer Determined by gel filtration. Has additional ankyrin repeats. i 0.133 https://doi.org/10.1128/aem.03523-13 brenda-enzymes.org i 3380.0 https://doi.org/10.1128/aem.03523-13 676 https://doi.org/10.1128/aem.03523-13 ESP 1-5-16 /html-files/class1-family16.html EcAI Identical sequences: P0A963, P0A962 i P0A962 https://www.uniprot.org/uniprotkb/P0A962/entry ASPG1_ECOLI 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Escherichia coli (strain K12) i Cytoplasm 338 Homo tetramer dimer of two intimate dimers i 2HIM https://www.rcsb.org/structure/2HIM https://www.uniprot.org/uniprotkb/P0A962/entry#structure 1.2;3.5 https://doi.org/10.1016/j.jmb.2007.03.061;https://doi.org/10.1128/jb.118.1.231-241.1974 S_0.5, allosteric enzyme i ESP 1-5-16 /html-files/class1-family16.html - A0A221KKE2 https://www.uniprot.org/uniprotkb/A0A221KKE2/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Halomonas elongata - 355 - 5.6 https://doi.org/10.1007/s00253-017-8456-5 1960 https://doi.org/10.1007/s00253-017-8456-5 ESP 1-5-16 /html-files/class1-family16.html - X0NLX5 https://www.uniprot.org/uniprotkb/X0NLX5/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Photobacterium leiognathi Fish gut microbiome. Organism not certain. i - 337 - 3.008 https://doi.org/10.1007/s00253-022-11954-7 Sequence may not be exact match i ESP 1-5-16 /html-files/class1-family16.html - As presented, lacks the critical conserved Motif 1 i A0A7D7L7P6 https://www.uniprot.org/uniprotkb/A0A7D7L7P6/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pseudomonas aeruginosa - 306 - 10.904 https://doi.org/10.1007/s10126-022-10129-9 ESP 1-5-16 /html-files/class1-family16.html - A0A2D5S0K3 https://www.uniprot.org/uniprotkb/A0A2D5S0K3/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Rheinheimera sp - 341 - 0.98 https://doi.org/10.1016/j.bej.2023.108806 16.17 https://doi.org/10.1016/j.bej.2023.108806 ESP 1-5-16 /html-files/class1-family16.html VcA, type I Q9KQK3 https://www.uniprot.org/uniprotkb/Q9KQK3/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Vibrio cholerae Cytoplasm 337 Homo tetramer 2OCD https://www.rcsb.org/structure/2OCD Paper to be published i 1.1 https://doi.org/10.1016/j.ijbiomac.2017.12.165 Sequence may not be exact match i 4424 https://doi.org/10.1016/j.ijbiomac.2017.12.165 Sequence may not be exact match i ESP 1-5-16 /html-files/class1-family16.html - A0A191W2U6 https://www.uniprot.org/uniprotkb/A0A191W2U6/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Vibrio sp. - 337 - 4.517 https://doi.org/10.1016/j.biochi.2025.03.003 2.88 https://doi.org/10.1016/j.biochi.2025.03.003 ESP 1-5-16 /html-files/class1-family16.html YpAI A0A3N4B0Q2 https://www.uniprot.org/uniprotkb/A0A3N4B0Q2/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Yersinia pestis Cytoplasm 338 Homo dimer / tetramer 7R69 https://www.rcsb.org/structure/7R69 https://www.uniprot.org/uniprotkb/A0A3N4B0Q2/entry#structure 6.0 https://doi.org/10.1111/febs.16635 K_0.5 i 42.0 https://doi.org/10.1111/febs.16635 ESP 2-1-2 /html-files/class2-family2.html - D0V0N4 https://www.uniprot.org/uniprotkb/D0V0N4/entry 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Asobara tabida Venom 362 - 4.051 https://doi.org/10.1371/journal.pone.0181940 ESP 2-1-2 /html-files/class2-family2.html - P20933 https://www.uniprot.org/uniprotkb/P20933/entry ASPG_HUMAN 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Homo sapiens Lysosome 346 Hetero tetramer / homo dimer 1APY https://www.rcsb.org/structure/1APY https://www.uniprot.org/uniprotkb/P20933/entry#structure 0.656 https://doi.org/10.1016/S0014-5793(97)00761-8 Sequence may not be exact match i ESP 2-1-2 /html-files/class2-family2.html - A0A141NXG8 https://www.uniprot.org/uniprotkb/A0A141NXG8/entry 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Leptopilina heterotoma Venom 367 - 1.188 https://doi.org/10.1371/journal.pone.0181940 ESP 2-1-2 /html-files/class2-family2.html - O02467 https://www.uniprot.org/uniprotkb/O02467/entry ASPG_SPOFR 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Spodoptera frugiperda Lysosome 320 - 3.0 https://doi.org/10.1093/glycob/6.5.527 ESP 2-1-5 /html-files/class2-family5.html - A0A1V3U2Z4 https://www.uniprot.org/uniprotkb/A0A1V3U2Z4/entry 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Elizabethkingia meningoseptica - 331 Hetero tetramer / homo dimer 6DEY https://www.rcsb.org/structure/6DEY ESP 2-1-5 /html-files/class2-family5.html - Q47898 https://www.uniprot.org/uniprotkb/Q47898/entry ASPG_ELIMR 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Elizabethkingia miricola Periplasm 340 Hetero tetramer / homo dimer 1AYY https://www.rcsb.org/structure/1AYY https://www.uniprot.org/uniprotkb/Q47898/entry#structure ESP 2-2-6 /html-files/class2-family6.html - Q8YQB1 https://www.uniprot.org/uniprotkb/Q8YQB1/entry ASGX_NOSS1 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Nostoc sp. - 318 - 2.0 https://doi.org/10.1042/bj3640129 2.2 https://doi.org/10.1042/bj3640129 ESP 2-2-6 /html-files/class2-family6.html - P74383 https://www.uniprot.org/uniprotkb/P74383/entry ASGX_SYNY3 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Synechocystis sp. - 329 - 0.66 https://doi.org/10.1042/bj3640129 1.6 https://doi.org/10.1042/bj3640129 ESP 2-3-9 /html-files/class2-family9.html - Q9H6P5 https://www.uniprot.org/uniprotkb/Q9H6P5/entry TASP1_HUMAN 3.4.25.- https://enzyme.expasy.org/EC/3.4.25.- Homo sapiens - Overexpressed in primary human cancers. https://doi.org/10.1016/j.str.2021.03.008 i 420 Hetero tetramer / homo dimer / hexamer Concentration dependent. i 6VIN https://www.rcsb.org/structure/6VIN https://www.uniprot.org/uniprotkb/Q9H6P5/entry#structure ESP 2-4-10 /html-files/class2-family10.html - A0A0N7IWY2 https://www.uniprot.org/uniprotkb/A0A0N7IWY2/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Aquabacterium sp. - 306 - 33.7 https://doi.org/10.1007/s10482-015-0614-0 0.0087 https://doi.org/10.1007/s10482-015-0614-0 ESP 2-4-10 /html-files/class2-family10.html - Q6L1Z2 https://www.uniprot.org/uniprotkb/Q6L1Z2/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Picrophilus torridus - 297 - 11.69 https://doi.org/10.1021/acsomega.2c01127 0.056 https://doi.org/10.1021/acsomega.2c01127 ESP 2-4-10 /html-files/class2-family10.html - A3MUS8 https://www.uniprot.org/uniprotkb/A3MUS8/entry ASPGP_PYRCJ 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pyrobaculum calidifontis - 299 Dimer Determined from gel filtration i 4.5 https://doi.org/10.1007/s12223-018-0656-6 355 https://doi.org/10.1007/s12223-018-0656-6 374.0 https://doi.org/10.1007/s12223-018-0656-6 ESP 2-4-10 /html-files/class2-family10.html - Q9V262 https://www.uniprot.org/uniprotkb/Q9V262/entry ASPGP_PYRAB 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pyrococcus abyssi - 305 - 2.051 https://doi.org/10.1590/1519-6984.244735 ESP 2-4-10 /html-files/class2-family10.html - Q5JHT1 https://www.uniprot.org/uniprotkb/Q5JHT1/entry ASPGP_THEKO 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Thermococcus kodakarensis - 306 Dimer Determined from gel filtration i 3.1 https://doi.org/10.1016/j.ijbiomac.2020.01.012 833 https://doi.org/10.1016/j.ijbiomac.2020.01.012 ESP 2-4-12 /html-files/class2-family12.html CpAIII H0VQC8 https://www.uniprot.org/uniparc/UPI000184D93B/entry 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Cavia porcellus - 332 Hetero tetramer / homo dimer 4O47 https://www.rcsb.org/structure/4O47 2.24 https://doi.org/10.1021/bi401692v 3.95 https://doi.org/10.1021/bi401692v ESP 2-4-12 /html-files/class2-family12.html - Q7L266 https://www.uniprot.org/uniprotkb/Q7L266/entry ASGL1_HUMAN 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Homo sapiens Cytoplasm 308 Hetero tetramer / homo dimer 4ZM9 https://www.rcsb.org/structure/4ZM9 https://www.uniprot.org/uniprotkb/Q7L266/entry#structure 3.4 https://doi.org/10.1002/mrd.10092 6.9 https://doi.org/10.1002/mrd.10092 ESP 2-4-12 /html-files/class2-family12.html - Q8VI04 https://www.uniprot.org/uniprotkb/Q8VI04/entry ASGL1_RAT 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Rattus norvegicus Cytoplasm 333 - 2.4 https://doi.org/10.1046/j.1471-4159.2003.01766.x ESP 2-5-14 /html-files/class2-family14.html - P50287 https://www.uniprot.org/uniprotkb/P50287/entry ASPGA_ARATH 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Arabidopsis thaliana - 315 - > 4 https://doi.org/10.1042/bj3640129 ESP 2-5-14 /html-files/class2-family14.html EcAIII P37595 https://www.uniprot.org/uniprotkb/P37595/entry IAAA_ECOLI 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Escherichia coli - 321 Hetero tetramer / homo dimer 1T3M https://www.rcsb.org/structure/1T3M https://www.uniprot.org/uniprotkb/P37595/entry#structure 3.9 https://doi.org/10.1111/j.1432-1033.2004.04254.x 0.28 https://doi.org/10.1111/j.1432-1033.2004.04254.x ESP 2-5-14 /html-files/class2-family14.html LlAIII Q9ZSD6 https://www.uniprot.org/uniprotkb/Q9ZSD6/entry ASPG_LUPLU 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Lupinus luteus - 325 Hetero tetramer / homo dimer 2GEZ https://www.rcsb.org/structure/2GEZ https://www.uniprot.org/uniprotkb/Q9ZSD6/entry#structure 4.8 https://doi.org/10.1111/j.1432-1033.2004.04254.x 0.32 https://doi.org/10.1111/j.1432-1033.2004.04254.x ESP 2-5-14 /html-files/class2-family14.html PvAIII V7CU13 https://www.uniprot.org/uniprotkb/V7CU13/entry 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Phaseolus vulgaris - 326 Hetero tetramer / homo dimer 4PU6 https://www.rcsb.org/structure/4PU6 https://www.uniprot.org/uniprotkb/V7CU13/entry#structure ESP 2-5-14 /html-files/class2-family14.html - UPI002B2CA93D https://www.uniprot.org/uniparc/UPI002B2CA93D/entry 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Solanum lycopersicum - 329 - 0.66 https://doi.org/10.1021/acsomega.3c07633 ESP 2-5-17 /html-files/class2-family17.html - X7EBZ8 https://www.uniprot.org/uniprotkb/X7EBZ8/entry 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Roseivivax halodurans - 310 Hetero tetramer / homo dimer 8DQM https://www.rcsb.org/structure/8DQM https://www.uniprot.org/uniprotkb/X7EBZ8/entry#structure ESP 3-1-1 /html-files/class3-family1.html - A0A0C5GVW3 https://www.uniprot.org/uniprotkb/A0A0C5GVW3/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Paenibacillus barengoltzii - 336 Monomer Determined by gel filtration. i 3.6 https://doi.org/10.1016/j.ijbiomac.2016.11.115 162.2 https://doi.org/10.1016/j.ijbiomac.2016.11.115 ESP 3-1-1 /html-files/class3-family1.html - A0A068N0Z8 https://www.uniprot.org/uniprotkb/A0A068N0Z8/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Synechocystis sp. - 317 - 29 https://doi.org/10.1134/S000629791610014X 25.7 https://doi.org/10.1134/S000629791610014X ESP 3-2-2 /html-files/class3-family2.html - W0KM71 https://www.uniprot.org/uniprotkb/W0KM71/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Nocardiopsis alba Extracellular 320 - 0.127 https://doi.org/10.1007/s00449-014-1277-3 5.5 https://doi.org/10.1007/s00449-014-1277-3 ESP 3-2-2 /html-files/class3-family2.html - Q54237 https://www.uniprot.org/uniprotkb/Q54237/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Streptomyces griseus Extracellular 328 - ESP 3-3-3 /html-files/class3-family3.html ReAV Q2K0Z2 https://www.uniprot.org/uniprotkb/Q2K0Z2/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Rhizobium etli - 367 Homo dimer 7OS6 https://www.rcsb.org/structure/7OS6 https://www.uniprot.org/uniprotkb/Q2K0Z2/entry#structure 4.2 https://doi.org/10.1038/s41467-021-27105-x 438 https://doi.org/10.1038/s41467-021-27105-x ESP 3-4-4 /html-files/class3-family4.html ReAIV Q2KB35 https://www.uniprot.org/uniprotkb/Q2KB35/entry 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Rhizobium etli - 335 Homo dimer 8CLZ https://www.rcsb.org/structure/8CLZ https://www.uniprot.org/uniprotkb/Q2KB35/entry#structure 1.34 https://doi.org/10.1107/S2059798323005648 411 https://doi.org/10.1107/S2059798323005648 Swiss-Prot 1-1-1 /html-files/class1-family1.html ScAII Identical sequences: P0CZ17, P0CX77, P0CX78, P0CX79 i P0CZ17 https://www.uniprot.org/uniprotkb/P0CZ17/entry ASP21_YEAST 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Saccharomyces cerevisiae Secreted 362 - 0.27 https://doi.org/10.1016/s0021-9258(17)38144-9 42 https://doi.org/10.1016/s0021-9258(17)38144-9 Swiss-Prot 1-1-1 /html-files/class1-family1.html ScAII Identical sequences: P0CZ17, P0CX77, P0CX78, P0CX79 i P0CX77 https://www.uniprot.org/uniprotkb/P0CX77/entry ASP22_YEAST 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Saccharomyces cerevisiae Secreted 362 - 0.27 https://doi.org/10.1016/s0021-9258(17)38144-9 42 https://doi.org/10.1016/s0021-9258(17)38144-9 Swiss-Prot 1-1-1 /html-files/class1-family1.html ScAII Identical sequences: P0CZ17, P0CX77, P0CX78, P0CX79 i P0CX78 https://www.uniprot.org/uniprotkb/P0CX78/entry ASP23_YEAST 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Saccharomyces cerevisiae Secreted 362 - 0.27 https://doi.org/10.1016/s0021-9258(17)38144-9 42 https://doi.org/10.1016/s0021-9258(17)38144-9 Swiss-Prot 1-1-1 /html-files/class1-family1.html ScAII Identical sequences: P0CZ17, P0CX77, P0CX78, P0CX79 i P0CX79 https://www.uniprot.org/uniprotkb/P0CX79/entry ASP24_YEAST 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Saccharomyces cerevisiae Secreted 362 - 0.27 https://doi.org/10.1016/s0021-9258(17)38144-9 42 https://doi.org/10.1016/s0021-9258(17)38144-9 Swiss-Prot 1-1-1 /html-files/class1-family1.html - P87015 https://www.uniprot.org/uniprotkb/P87015/entry ASPG1_SCHPO 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Schizosaccharomyces pombe Secreted, cell wall 360 - Swiss-Prot 1-1-1 /html-files/class1-family1.html ScAI P38986 https://www.uniprot.org/uniprotkb/P38986/entry ASPG1_YEAST 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Saccharomyces cerevisiae Cytoplasm 381 - 0.075 https://doi.org/10.1038/srep36239 K_0.5, allosteric enzyme i Swiss-Prot 1-1-1 /html-files/class1-family1.html - Q9UTS7 https://www.uniprot.org/uniprotkb/Q9UTS7/entry ASPG2_SCHPO 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Schizosaccharomyces pombe Secreted, cell wall 356 - Swiss-Prot 1-1-1 /html-files/class1-family1.html - Q8NKC0 https://www.uniprot.org/uniprotkb/Q8NKC0/entry ASPG3_SCHPO 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Schizosaccharomyces pombe Secreted, cell wall 360 - Swiss-Prot 1-1-1 /html-files/class1-family1.html - Q8TFF8 https://www.uniprot.org/uniprotkb/Q8TFF8/entry ASPG4_SCHPO 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Schizosaccharomyces pombe Secreted, cell wall 356 - Swiss-Prot 1-1-3 /html-files/class1-family3.html - O34482 https://www.uniprot.org/uniprotkb/O34482/entry ASPG2_BACSU 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus subtilis - 375 - 0.43 https://doi.org/10.1007/s00253-019-09967-w Swiss-Prot 1-1-3 /html-files/class1-family3.html EcAII P00805 https://www.uniprot.org/uniprotkb/P00805/entry ASPG2_ECOLI 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Escherichia coli Periplasm 348 Homo tetramer 3ECA https://www.rcsb.org/structure/3eca https://www.uniprot.org/uniprotkb/P00805/entry#structure 0.015 https://doi.org/10.1110/ps.9.10.2009 24 https://doi.org/10.1110/ps.9.10.2009 Swiss-Prot 1-1-3 /html-files/class1-family3.html - P43843 https://www.uniprot.org/uniprotkb/P43843/entry ASPG2_HAEIN 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Haemophilus influenzae Periplasm 349 - Swiss-Prot 1-1-3 /html-files/class1-family3.html ErA, type II P06608 https://www.uniprot.org/uniprotkb/P06608/entry ASPG_DICCH 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Dickeya chrysanthemi - 348 Homo tetramer 5F52 https://www.rcsb.org/structure/5F52 https://www.uniprot.org/uniprotkb/P06608/entry#structure 0.058 https://doi.org/10.1111/j.1742-4658.2009.06910.x Sequence may not be exact match. i 565 https://doi.org/10.1007/s12033-014-9766-9 Sequence may not be exact match. K_cat may not correspond to K_m. i Swiss-Prot 1-1-3 /html-files/class1-family3.html HpA, type II Q9ZLB9 https://www.uniprot.org/uniprotkb/Q9ZLB9/entry ASPG_HELPJ 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) i Cytoplasm 332 Homo tetramer PDBs https://www.uniprot.org/uniprotkb/Q9ZLB9/entry#structure 0.29 https://doi.org/10.1371/journal.pone.0117025 S_0.5, Sequence may not be exact match i 31.22 https://doi.org/10.1371/journal.pone.0117025 Sequence may not be exact match i 19.26 https://doi.org/10.1371/journal.pone.0117025 Sequence may not be exact match i Swiss-Prot 1-1-3 /html-files/class1-family3.html HpA, type II O25424 https://www.uniprot.org/uniprotkb/O25424/entry ASPG_HELPY 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) i Cytoplasm 330 - Swiss-Prot 1-1-3 /html-files/class1-family3.html WsA, type II P50286 https://www.uniprot.org/uniprotkb/P50286/entry ASPG_WOLSU 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Wolinella succinogenes Cytoplasm 330 Homo tetramer 1WSA https://www.rcsb.org/structure/1WSA https://www.uniprot.org/uniprotkb/P50286/entry#structure 0.0217 https://doi.org/10.1038/srep41643 97.8 https://doi.org/10.1038/srep41643 Swiss-Prot 1-1-3 /html-files/class1-family3.html - P10172 https://www.uniprot.org/uniprotkb/P10172/entry ASPQ_ACIGL 3.5.1.38 https://enzyme.expasy.org/EC/3.5.1.38 Acinetobacter glutaminasificans Periplasm 331 Homo tetramer 1AGX https://www.rcsb.org/structure/1AGX Swiss-Prot 1-1-3 /html-files/class1-family3.html - Q9I407 https://www.uniprot.org/uniprotkb/Q9I407/entry ASPQ_PSEAE 3.5.1.38 https://enzyme.expasy.org/EC/3.5.1.38 Pseudomonas aeruginosa Periplasm 362 - Swiss-Prot 1-1-3 /html-files/class1-family3.html - O68897 https://www.uniprot.org/uniprotkb/O68897/entry ASPQ_PSEFA 3.5.1.38 https://enzyme.expasy.org/EC/3.5.1.38 Pseudomonas fluorescens Periplasm 362 - Swiss-Prot 1-1-3 /html-files/class1-family3.html - Q88K39 https://www.uniprot.org/uniprotkb/Q88K39/entry ASPQ_PSEPK 3.5.1.38 https://enzyme.expasy.org/EC/3.5.1.38 Pseudomonas putida Periplasm 362 - Swiss-Prot 1-1-3 /html-files/class1-family3.html - P10182 https://www.uniprot.org/uniprotkb/P10182/entry ASPQ_PSES7 3.5.1.38 https://enzyme.expasy.org/EC/3.5.1.38 Pseudomonas sp. Periplasm 337 Homo tetramer 3PGA https://www.rcsb.org/structure/3PGA https://www.uniprot.org/uniprotkb/P10182/entry#structure Swiss-Prot 1-2-5 /html-files/class1-family5.html BlA, type I P30363 https://www.uniprot.org/uniprotkb/P30363/entry ASPG_BACLI 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus licheniformis Cytoplasm 322 - Swiss-Prot 1-2-6 /html-files/class1-family6.html - Q9RRX9 https://www.uniprot.org/uniprotkb/Q9RRX9/entry ASPG_DEIRA 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Deinococcus radiodurans Cytoplasm 322 - Swiss-Prot 1-2-6 /html-files/class1-family6.html - P63628 https://www.uniprot.org/uniprotkb/P63628/entry ASPG_MYCBO 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Mycobacterium bovis Secreted 315 - Swiss-Prot 1-2-6 /html-files/class1-family6.html - Q9X7E6 https://www.uniprot.org/uniprotkb/Q9X7E6/entry ASPG_MYCLE 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Mycobacterium leprae Secreted 310 - Swiss-Prot 1-2-6 /html-files/class1-family6.html - P9WPX4 https://www.uniprot.org/uniprotkb/P9WPX4/entry ASPG_MYCTO 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), identical to P9WPX5 i Secreted 315 - Swiss-Prot 1-2-6 /html-files/class1-family6.html - P9WPX5 https://www.uniprot.org/uniprotkb/P9WPX5/entry ASPG_MYCTU 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), identical to P9WPX4 i Secreted 315 Dimer 0.38 8.3 19.57 https://doi.org/10.1016/j.biochi.2020.12.023 74.08 797.7 1587.7 https://doi.org/10.1016/j.biochi.2020.12.023 80.7 869.4 1732.5 https://doi.org/10.1016/j.biochi.2020.12.023 Swiss-Prot 1-4-11 /html-files/class1-family11.html - P26900 https://www.uniprot.org/uniprotkb/P26900/entry ASPG1_BACSU 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Bacillus subtilis Cytoplasm 329 - 1.579 https://doi.org/10.1007/s10123-024-00493-y Sequence may not be exact match i Swiss-Prot 1-4-11 /html-files/class1-family11.html - Q8TZE8 https://www.uniprot.org/uniprotkb/Q8TZE8/entry ASPG_PYRFU 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pyrococcus furiosus - 326 Homo dimer / tetramer Temperature dependent i 5CBP https://www.rcsb.org/structure/5CBP https://www.uniprot.org/uniprotkb/Q8TZE8/entry#structure 12 https://doi.org/10.1134/s0006297910030144 870 https://doi.org/10.1134/s0006297910030144 Swiss-Prot 1-4-11 /html-files/class1-family11.html - Q5JIW4 https://www.uniprot.org/uniprotkb/Q5JIW4/entry ASPG_THEKO 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Thermococcus kodakarensis - 328 Homo dimer 5OT0 https://www.rcsb.org/structure/5OT0 2.6;5.5 https://doi.org/10.1002/jobm.201300741;https://doi.org/10.1016/j.jbiosc.2013.04.005 1121;3300 https://doi.org/10.1002/jobm.201300741;https://doi.org/10.1016/j.jbiosc.2013.04.005 694 https://doi.org/10.1002/jobm.201300741 Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q9Y9T8 https://www.uniprot.org/uniprotkb/Q9Y9T8/entry GATD_AERPE 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Aeropyrum pernix - 427 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - O29380 https://www.uniprot.org/uniprotkb/O29380/entry GATD_ARCFU 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Archaeoglobus fulgidus - 418 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - B0R6H4 https://www.uniprot.org/uniprotkb/B0R6H4/entry GATD_HALS3 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Halobacterium salinarum - 427 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q9HP20 https://www.uniprot.org/uniprotkb/Q9HP20/entry GATD_HALSA 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Halobacterium salinarum - 427 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q18GL3 https://www.uniprot.org/uniprotkb/Q18GL3/entry GATD_HALWD 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Haloquadratum walsbyi - 442 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q8TR66 https://www.uniprot.org/uniprotkb/Q8TR66/entry GATD_METAC 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanosarcina acetivorans - 424 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q46GJ6 https://www.uniprot.org/uniprotkb/Q46GJ6/entry GATD_METBF 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanosarcina barkeri - 424 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q12X65 https://www.uniprot.org/uniprotkb/Q12X65/entry GATD_METBU 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanococcoides burtonii - 415 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q60331 https://www.uniprot.org/uniprotkb/Q60331/entry GATD_METJA 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanocaldococcus jannaschii - 417 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q8TV84 https://www.uniprot.org/uniprotkb/Q8TV84/entry GATD_METKA 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanopyrus kandleri - 458 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - A4FWR5 https://www.uniprot.org/uniprotkb/A4FWR5/entry GATD_METM5 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanococcus maripaludis - 418 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - A9AA46 https://www.uniprot.org/uniprotkb/A9AA46/entry GATD_METM6 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanococcus maripaludis - 418 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - A6VGK5 https://www.uniprot.org/uniprotkb/A6VGK5/entry GATD_METM7 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanococcus maripaludis - 418 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q8PUM7 https://www.uniprot.org/uniprotkb/Q8PUM7/entry GATD_METMA 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanosarcina mazei - 425 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - P61400 https://www.uniprot.org/uniprotkb/P61400/entry GATD_METMP 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanococcus maripaludis - 418 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - A5UK11 https://www.uniprot.org/uniprotkb/A5UK11/entry GATD_METS3 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanobrevibacter smithii - 436 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - A4YHH3 https://www.uniprot.org/uniprotkb/A4YHH3/entry GATD_METS5 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Metallosphaera sedula - 439 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q2NEH1 https://www.uniprot.org/uniprotkb/Q2NEH1/entry GATD_METST 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanosphaera stadtmanae - 438 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - O26802 https://www.uniprot.org/uniprotkb/O26802/entry GATD_METTH 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanothermobacter thermautotrophicus - 435 Hetero tetramer Has additional domain. i 2D6F https://www.rcsb.org/structure/2D6F Swiss-Prot 1-4-12 /html-files/class1-family12.html - A6UPR4 https://www.uniprot.org/uniprotkb/A6UPR4/entry GATD_METVS 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Methanococcus vannielii - 426 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - P61401 https://www.uniprot.org/uniprotkb/P61401/entry GATD_NANEQ 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Nanoarchaeum equitans - 392 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q9V0T9 https://www.uniprot.org/uniprotkb/Q9V0T9/entry GATD_PYRAB 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Pyrococcus abyssi - 438 Hetero tetramer Has additional domain. i 1ZQ1 https://www.rcsb.org/structure/1ZQ1 Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q8ZY04 https://www.uniprot.org/uniprotkb/Q8ZY04/entry GATD_PYRAE 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Pyrobaculum aerophilum - 417 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q8U0X0 https://www.uniprot.org/uniprotkb/Q8U0X0/entry GATD_PYRFU 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Pyrococcus furiosus - 438 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - O59132 https://www.uniprot.org/uniprotkb/O59132/entry GATD_PYRHO 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Pyrococcus horikoshii - 438 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q97ZH5 https://www.uniprot.org/uniprotkb/Q97ZH5/entry GATD_SACS2 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Saccharolobus solfataricus - 444 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q4J955 https://www.uniprot.org/uniprotkb/Q4J955/entry GATD_SULAC 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Sulfolobus acidocaldarius - 446 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - C3N5E7 https://www.uniprot.org/uniprotkb/C3N5E7/entry GATD_SULIA 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Sulfolobus islandicus - 445 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - C4KH13 https://www.uniprot.org/uniprotkb/C4KH13/entry GATD_SULIK 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Sulfolobus islandicus - 445 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - C3MPS1 https://www.uniprot.org/uniprotkb/C3MPS1/entry GATD_SULIL 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Sulfolobus islandicus - 445 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - C3MYR5 https://www.uniprot.org/uniprotkb/C3MYR5/entry GATD_SULIM 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Sulfolobus islandicus - 445 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - C3NHQ2 https://www.uniprot.org/uniprotkb/C3NHQ2/entry GATD_SULIN 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Sulfolobus islandicus - 445 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - C3NE01 https://www.uniprot.org/uniprotkb/C3NE01/entry GATD_SULIY 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Sulfolobus islandicus - 445 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q971W5 https://www.uniprot.org/uniprotkb/Q971W5/entry GATD_SULTO 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Sulfurisphaera tokodaii - 448 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q9HJJ5 https://www.uniprot.org/uniprotkb/Q9HJJ5/entry GATD_THEAC 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Thermoplasma acidophilum - 409 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q5JI77 https://www.uniprot.org/uniprotkb/Q5JI77/entry GATD_THEKO 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Thermococcus kodakarensis - 440 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - A1RX40 https://www.uniprot.org/uniprotkb/A1RX40/entry GATD_THEPD 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Thermofilum pendens - 451 - Swiss-Prot 1-4-12 /html-files/class1-family12.html - Q979L8 https://www.uniprot.org/uniprotkb/Q979L8/entry GATD_THEVO 6.3.5.- https://enzyme.expasy.org/EC/6.3.5.- Thermoplasma volcanium - 406 - Swiss-Prot 1-5-14 /html-files/class1-family14.html - Q9U518 https://www.uniprot.org/uniprotkb/Q9U518/entry ASPG_DIRIM 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Dirofilaria immitis - 590 - Swiss-Prot 1-5-14 /html-files/class1-family14.html hAI Q86U10 https://www.uniprot.org/uniprotkb/Q86U10/entry LPP60_HUMAN 3.1.1.5;3.5.1.1;3.1.1.47 https://enzyme.expasy.org/EC/3.1.1.5;https://enzyme.expasy.org/EC/3.5.1.1;https://enzyme.expasy.org/EC/3.5.1.47 Homo sapiens - 573 Monomer At assay conditions, substrate-inducing effect on the oligomeric state. Has additional ankyrin repeats. i 11.5 https://www.jbc.org/article/S0021-9258(20)38784-6/fulltext S_0.5, allosteric enzyme i 6.7 https://www.jbc.org/article/S0021-9258(20)38784-6/fulltext Swiss-Prot 1-5-14 /html-files/class1-family14.html - A0JNU3 https://www.uniprot.org/uniprotkb/A0JNU3/entry LPP60_MOUSE 3.1.1.5;3.5.1.1;3.1.1.47 https://enzyme.expasy.org/EC/3.1.1.5;https://enzyme.expasy.org/EC/3.5.1.1;https://enzyme.expasy.org/EC/3.5.1.47 Mus musculus - 564 - Swiss-Prot 1-5-14 /html-files/class1-family14.html - O88202 https://www.uniprot.org/uniprotkb/O88202/entry LPP60_RAT 3.1.1.5;3.5.1.1;3.1.1.47 https://enzyme.expasy.org/EC/3.1.1.5;https://enzyme.expasy.org/EC/3.5.1.1;https://enzyme.expasy.org/EC/3.5.1.47 Rattus norvegicus - 564 - Swiss-Prot 1-5-16 /html-files/class1-family16.html EcAI Identical sequences: P0A963, P0A962 i P0A963 https://www.uniprot.org/uniprotkb/P0A963/entry ASPG1_ECO57 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Escherichia coli (O157:H7) i Cytoplasm 338 - Swiss-Prot 1-5-16 /html-files/class1-family16.html EcAI Identical sequences: P0A963, P0A962 i P0A962 https://www.uniprot.org/uniprotkb/P0A962/entry ASPG1_ECOLI 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Escherichia coli (strain K12) i Cytoplasm 338 Homo tetramer dimer of two intimate dimers i 2HIM https://www.rcsb.org/structure/2HIM https://www.uniprot.org/uniprotkb/P0A962/entry#structure 1.2;3.5 https://doi.org/10.1016/j.jmb.2007.03.061;https://doi.org/10.1128/jb.118.1.231-241.1974 S_0.5, allosteric enzyme i Swiss-Prot 2-1-2 /html-files/class2-family2.html - Q56W64 https://www.uniprot.org/uniprotkb/Q56W64/entry ASPG3_ARATH 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Arabidopsis thaliana - 359 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - Q21697 https://www.uniprot.org/uniprotkb/Q21697/entry ASPG_CAEEL 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Caenorhabditis elegans Lysosome 363 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B3MJ16 https://www.uniprot.org/uniprotkb/B3MJ16/entry ASPG2_DROAN 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila ananassae - 378 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B3N6Y7 https://www.uniprot.org/uniprotkb/B3N6Y7/entry ASPG1_DROER 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila erecta - 396 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B3NN96 https://www.uniprot.org/uniprotkb/B3NN96/entry ASPG2_DROER 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila erecta - 399 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B4JVW6 https://www.uniprot.org/uniprotkb/B4JVW6/entry ASPG1_DROGR 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila grimshawi - 393 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - Q8MR45 https://www.uniprot.org/uniprotkb/Q8MR45/entry ASPG1_DROME 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila melanogaster - 393 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - Q9W2C3 https://www.uniprot.org/uniprotkb/Q9W2C3/entry ASPG2_DROME 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila melanogaster - 397 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B4GGF2 https://www.uniprot.org/uniprotkb/B4GGF2/entry ASPG1_DROPE 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila persimilis - 388 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B4GHE3 https://www.uniprot.org/uniprotkb/B4GHE3/entry ASPG2_DROPE 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila persimilis - 457 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - Q28Y14 https://www.uniprot.org/uniprotkb/Q28Y14/entry ASPG1_DROPS 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila pseudoobscura - 388 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - Q28XQ5 https://www.uniprot.org/uniprotkb/Q28XQ5/entry ASPG2_DROPS 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila pseudoobscura - 457 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B4HT15 https://www.uniprot.org/uniprotkb/B4HT15/entry ASPG1_DROSE 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila sechellia - 393 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B4I7X1 https://www.uniprot.org/uniprotkb/B4I7X1/entry ASPG2_DROSE 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila sechellia - 397 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B4QHB1 https://www.uniprot.org/uniprotkb/B4QHB1/entry ASPG1_DROSI 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila simulans - 393 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B4QGM0 https://www.uniprot.org/uniprotkb/B4QGM0/entry ASPG2_DROSI 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila simulans - 397 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B4NWI1 https://www.uniprot.org/uniprotkb/B4NWI1/entry ASPG1_DROYA 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila yakuba - 396 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - B4P8E0 https://www.uniprot.org/uniprotkb/B4P8E0/entry ASPG2_DROYA 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Drosophila yakuba - 399 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - P20933 https://www.uniprot.org/uniprotkb/P20933/entry ASPG_HUMAN 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Homo sapiens Lysosome 346 Hetero tetramer / homo dimer 1APY https://www.rcsb.org/structure/1APY https://www.uniprot.org/uniprotkb/P20933/entry#structure 0.656 https://doi.org/10.1016/S0014-5793(97)00761-8 Sequence may not be exact match i Swiss-Prot 2-1-2 /html-files/class2-family2.html - Q4R6C4 https://www.uniprot.org/uniprotkb/Q4R6C4/entry ASPG_MACFA 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Macaca fascicularis Lysosome 346 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - Q64191 https://www.uniprot.org/uniprotkb/Q64191/entry ASPG_MOUSE 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Mus musculus Lysosome 346 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - P30919 https://www.uniprot.org/uniprotkb/P30919/entry ASPG_RAT 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Rattus norvegicus Lysosome 345 - Swiss-Prot 2-1-2 /html-files/class2-family2.html - O02467 https://www.uniprot.org/uniprotkb/O02467/entry ASPG_SPOFR 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Spodoptera frugiperda Lysosome 320 - 3.0 https://doi.org/10.1093/glycob/6.5.527 Swiss-Prot 2-1-5 /html-files/class2-family5.html - Q47898 https://www.uniprot.org/uniprotkb/Q47898/entry ASPG_ELIMR 3.5.1.26 https://enzyme.expasy.org/EC/3.5.1.26 Elizabethkingia miricola Periplasm 340 Hetero tetramer / homo dimer 1AYY https://www.rcsb.org/structure/1AYY https://www.uniprot.org/uniprotkb/Q47898/entry#structure Swiss-Prot 2-2-6 /html-files/class2-family6.html - Q8YQB1 https://www.uniprot.org/uniprotkb/Q8YQB1/entry ASGX_NOSS1 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Nostoc sp. - 318 - 2.0 https://doi.org/10.1042/bj3640129 2.2 https://doi.org/10.1042/bj3640129 Swiss-Prot 2-2-6 /html-files/class2-family6.html - P74383 https://www.uniprot.org/uniprotkb/P74383/entry ASGX_SYNY3 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Synechocystis sp. - 329 - 0.66 https://doi.org/10.1042/bj3640129 1.6 https://doi.org/10.1042/bj3640129 Swiss-Prot 2-3-7 /html-files/class2-family7.html - Q9P6N7 https://www.uniprot.org/uniprotkb/Q9P6N7/entry TASP1_SCHPO 3.4.25.- https://enzyme.expasy.org/EC/3.4.25.- Schizosaccharomyces pombe Cytoplasm 345 - Swiss-Prot 2-3-8 /html-files/class2-family8.html - O65268 https://www.uniprot.org/uniprotkb/O65268/entry TASP1_ARATH 3.4.25.- https://enzyme.expasy.org/EC/3.4.25.- Arabidopsis thaliana - 408 - Swiss-Prot 2-3-9 /html-files/class2-family9.html Taspase1 Q9H6P5 https://www.uniprot.org/uniprotkb/Q9H6P5/entry TASP1_HUMAN 3.4.25.- https://enzyme.expasy.org/EC/3.4.25.- Homo sapiens - Overexpressed in primary human cancers. https://doi.org/10.1016/j.str.2021.03.008 i 420 Hetero tetramer / homo dimer / hexamer Concentration dependent. i 6VIN https://www.rcsb.org/structure/6VIN https://www.uniprot.org/uniprotkb/Q9H6P5/entry#structure Swiss-Prot 2-3-9 /html-files/class2-family9.html - Q8R1G1 https://www.uniprot.org/uniprotkb/Q8R1G1/entry TASP1_MOUSE 3.4.25.- https://enzyme.expasy.org/EC/3.4.25.- Mus musculus - 420 - Swiss-Prot 2-4-10 /html-files/class2-family10.html - A3MUS8 https://www.uniprot.org/uniprotkb/A3MUS8/entry ASPGP_PYRCJ 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pyrobaculum calidifontis - 299 Dimer Determined from gel filtration i 4.5 https://doi.org/10.1007/s12223-018-0656-6 355 https://doi.org/10.1007/s12223-018-0656-6 374.0 https://doi.org/10.1007/s12223-018-0656-6 Swiss-Prot 2-4-10 /html-files/class2-family10.html - Q9V262 https://www.uniprot.org/uniprotkb/Q9V262/entry ASPGP_PYRAB 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pyrococcus abyssi - 305 - 2.051 https://doi.org/10.1590/1519-6984.244735 Swiss-Prot 2-4-10 /html-files/class2-family10.html - Q8U4E6 https://www.uniprot.org/uniprotkb/Q8U4E6/entry ASPGP_PYRFU 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pyrococcus furiosus - 306 - Swiss-Prot 2-4-10 /html-files/class2-family10.html - O57971 https://www.uniprot.org/uniprotkb/O57971/entry ASPGP_PYRHO 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Pyrococcus horikoshii - 305 - Swiss-Prot 2-4-10 /html-files/class2-family10.html - Q5JHT1 https://www.uniprot.org/uniprotkb/Q5JHT1/entry ASPGP_THEKO 3.5.1.1 https://enzyme.expasy.org/EC/3.5.1.1 Thermococcus kodakarensis - 306 Dimer Determined from gel filtration i 3.1 https://doi.org/10.1016/j.ijbiomac.2020.01.012 833 https://doi.org/10.1016/j.ijbiomac.2020.01.012 Swiss-Prot 2-4-12 /html-files/class2-family12.html - Q32LE5 https://www.uniprot.org/uniprotkb/Q32LE5/entry ASGL1_BOVIN 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Bos taurus Cytoplasm 308 - Swiss-Prot 2-4-12 /html-files/class2-family12.html - Q5BKW9 https://www.uniprot.org/uniprotkb/Q5BKW9/entry ASGL1_DANRE 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Danio rerio Cytoplasm 310 - Swiss-Prot 2-4-12 /html-files/class2-family12.html - Q9VXT7 https://www.uniprot.org/uniprotkb/Q9VXT7/entry ASGL1_DROME 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Drosophila melanogaster - 332 - Swiss-Prot 2-4-12 /html-files/class2-family12.html - Q29I93 https://www.uniprot.org/uniprotkb/Q29I93/entry ASGL1_DROPS 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Drosophila pseudoobscura - 325 - Swiss-Prot 2-4-12 /html-files/class2-family12.html - Q7L266 https://www.uniprot.org/uniprotkb/Q7L266/entry ASGL1_HUMAN 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Homo sapiens Cytoplasm 308 Hetero tetramer / homo dimer 4ZM9 https://www.rcsb.org/structure/4ZM9 https://www.uniprot.org/uniprotkb/Q7L266/entry#structure 3.4 https://doi.org/10.1002/mrd.10092 6.9 https://doi.org/10.1002/mrd.10092 Swiss-Prot 2-4-12 /html-files/class2-family12.html - Q4R7U8 https://www.uniprot.org/uniprotkb/Q4R7U8/entry ASGL1_MACFA 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Macaca fascicularis Cytoplasm 308 - Swiss-Prot 2-4-12 /html-files/class2-family12.html - Q8C0M9 https://www.uniprot.org/uniprotkb/Q8C0M9/entry ASGL1_MOUSE 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Mus musculus Cytoplasm 326 - Swiss-Prot 2-4-12 /html-files/class2-family12.html - Q8VI04 https://www.uniprot.org/uniprotkb/Q8VI04/entry ASGL1_RAT 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Rattus norvegicus Cytoplasm 333 - 2.4 https://doi.org/10.1046/j.1471-4159.2003.01766.x Swiss-Prot 2-4-12 /html-files/class2-family12.html - Q6GM78 https://www.uniprot.org/uniprotkb/Q6GM78/entry ASGL1_XENLA 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Xenopus laevis Cytoplasm 309 - Swiss-Prot 2-5-14 /html-files/class2-family14.html - P50287 https://www.uniprot.org/uniprotkb/P50287/entry ASPGA_ARATH 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Arabidopsis thaliana - 315 - > 4 https://doi.org/10.1042/bj3640129 Swiss-Prot 2-5-14 /html-files/class2-family14.html - Q8GXG1 https://www.uniprot.org/uniprotkb/Q8GXG1/entry ASPGB_ARATH 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Arabidopsis thaliana - 325 - Swiss-Prot 2-5-14 /html-files/class2-family14.html - Q54WW4 https://www.uniprot.org/uniprotkb/Q54WW4/entry ASGX_DICDI 3.4.19.5;3.5.1.1 https://enzyme.expasy.org/EC/3.4.19.5;https://enzyme.expasy.org/EC/3.5.1.1 Dictyostelium discoideum - 346 - Swiss-Prot 2-5-14 /html-files/class2-family14.html EcAIII P37595 https://www.uniprot.org/uniprotkb/P37595/entry IAAA_ECOLI 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Escherichia coli - 321 Hetero tetramer / homo dimer 1T3M https://www.rcsb.org/structure/1T3M https://www.uniprot.org/uniprotkb/P37595/entry#structure 3.9 https://doi.org/10.1111/j.1432-1033.2004.04254.x 0.28 https://doi.org/10.1111/j.1432-1033.2004.04254.x Swiss-Prot 2-5-14 /html-files/class2-family14.html - P50288 https://www.uniprot.org/uniprotkb/P50288/entry ASPG_LUPAL 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Lupinus albus - 325 - Swiss-Prot 2-5-14 /html-files/class2-family14.html - P30364 https://www.uniprot.org/uniprotkb/P30364/entry ASPG_LUPAN 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Lupinus angustifolius - 325 - Swiss-Prot 2-5-14 /html-files/class2-family14.html - P30362 https://www.uniprot.org/uniprotkb/P30362/entry ASPG_LUPAR 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Lupinus arboreus - 306 - Swiss-Prot 2-5-14 /html-files/class2-family14.html LlAIII Q9ZSD6 https://www.uniprot.org/uniprotkb/Q9ZSD6/entry ASPG_LUPLU 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Lupinus luteus - 325 Hetero tetramer / homo dimer 2GEZ https://www.rcsb.org/structure/2GEZ https://www.uniprot.org/uniprotkb/Q9ZSD6/entry#structure 4.8 https://doi.org/10.1111/j.1432-1033.2004.04254.x 0.32 https://doi.org/10.1111/j.1432-1033.2004.04254.x Swiss-Prot 2-5-14 /html-files/class2-family14.html - Q7CQV5 https://www.uniprot.org/uniprotkb/Q7CQV5/entry IAAA_SALTY 3.4.19.5 https://enzyme.expasy.org/EC/3.4.19.5 Salmonella typhimurium - 313 -