2 experimentally studied proteins
0 sequences in Swiss-Prot
7,794 unique sequences in UniRef100
Almost exclusively sequences from bacteria in the Actinomycetota phylum
High affinity to L-asparagine
Putative extracellular enzymes
Clan 2: Family 2
| Fam ? Class - Clan - Family | Alt ? Alternative historical name / classification | AN ? UniProt accession number | Name ? UniProt entry name, only given here for Swiss-Prot entries | EC | Organism | Cell-Loc | AAs | Structure | PDB | Km i for Asn [mM] | Vmax i for Asn [μmol/min/mg] | Kcat i for Asn [s-1] | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3-2-2 | - | W0KM71 | 3.5.1.1 | Nocardiopsis alba | Extracellular | 320 | - | - | 0.127 | 5.5 | - | ||
| 3-2-2 | - | Q54237 | 3.5.1.1 | Streptomyces griseus | Extracellular (putative) | 328 | - | - | - | - | - |
Clan 2 and Family 2 consist of sequences from the Actinomycetota phylum, like the extracellular Streptomyces griseus L-asparaginase (Q54237) or the Nocardiopsis alba L-asparaginase (W0KM71) with an intriguing Km for L-asparagine in the micromolar range (not far from the Km of ErAII) and no detected L-glutaminase activity.
