Class 3 Family 2

Family 2 Overview

2 experimentally studied proteins

0 sequences in Swiss-Prot

7,794 unique sequences in UniRef100

Almost exclusively sequences from bacteria in the Actinomycetota phylum

High affinity to l‑asparagine

Putative extracellular enzymes

Clan 2: Family 2

Reference Monomer^A

Reference Structure

Family 2 Motifs
(W0KM71)

Experimentally Studied Proteins

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]

Swiss-Prot Sequences

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]

UniRef100 Sequences^B

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Representative Sequence Alignment

Additional Information

Clan 2 and Family 2 consist of sequences from the Actinomycetota phylum, like the extracellular Streptomyces griseus l‑asparaginase (Q54237) or the Nocardiopsis alba l‑asparaginase (W0KM71) with an intriguing Km for l‑asparagine in the micromolar range (not far from the Km of ErAII) and no detected l‑glutaminase activity.