Class 2 Family 12

Family 12 Overview

3 experimentally studied proteins

9 sequences in Swiss-Prot

2,384 unique sequences in UniRef100

Mostly metazoan l‑asparaginases/isoaspartyl peptidases

Clan 4: Family 10, Family 11, Family 12

Reference Monomer¹

Reference Structure

Family 12 Motifs
(Q7L266)

Experimentally Studied Proteins

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]

Swiss-Prot Sequences

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]

UniRef100 Sequences²

Download FASTA

Preparing download link...

Representative Sequence Alignment

Additional Information

Clan 4 enzymes are isoaspartyl peptidases and/or l‑asparaginases.

Family 12 l‑asparaginases/isoaspartyl peptidases are mostly from metazoans, like the cytoplasmic Homo sapiens enzyme (Q7L266). The structure has been solved for two proteins in this family.

¹Varadi, M et al. AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Research (2024). Licensed under CC BY 4.0.

²Suzek, B.E. et al. UniRef: comprehensive and non-redundant UniProt reference clusters. Bioinformatics (2007). Licensed under CC BY 4.0. Added classification code to sequence headers.