1 experimentally studied protein
2 sequences in Swiss-Prot
2,702 unique sequences in UniRef100
Threonine aspartases from metazoans and fungi
Unique hexameric structure (concentration dependent)
| Fam ? Class - Clan - Family | Alt ? Alternative historical name / classification | AN ? UniProt accession number | Name ? UniProt entry name, only given here for Swiss-Prot entries | EC | Organism | Cell-Loc | AAs | Structure | PDB | Km i for Asn [mM] | Vmax i for Asn [μmol/min/mg] | Kcat i for Asn [s-1] |
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| Fam ? Class - Clan - Family | Alt ? Alternative historical name / classification | AN ? UniProt accession number | Name ? UniProt entry name, only given here for Swiss-Prot entries | EC | Organism | Cell-Loc | AAs | Structure | PDB | Km i for Asn [mM] | Vmax i for Asn [μmol/min/mg] | Kcat i for Asn [s-1] |
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Clan 3 consists of three families, which are all eukaryotic threonine aspartases; many of these contain extra terminal amino acid residues compared to sequences in other clans.
Family 9 consists of threonine aspartases from metazoans and fungi, like the Homo sapiens enzyme (Q9H6P5), which can present as a tetramer or a hexamer depending on concentration. Taspase 1 is overexpressed in primary human cancer cells.
