Class 2 Family 6

Family 6 Overview

2 experimentally studied proteins

2 sequences in Swiss-Prot

1,905 unique sequences in UniRef100

Bacterial isoaspartyl peptidases

Clan 2: Family 6

Reference Monomer^A

Reference Structure

Family 6 Motifs
(P74383)

Experimentally Studied Proteins

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]

Swiss-Prot Sequences

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]

UniRef100 Sequences^B

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Representative Sequence Alignment

Additional Information

Clan 2 only contains one family: Family 6. Although it is not immediately obvious from the phylogenetic tree, sequences in this family are structurally and phylogenetically distant from neighbouring families and even from families that catalyse the same reaction. Family 6 enzymes are bacterial isoaspartyl peptidases, enzymes that hydrolyse a range of isoaspartyl dipeptides and l‑asparagine. Interestingly, the Synechocystis sp. isoaspartyl peptidase (P74383) technically has a Km for l‑asparagine in the higher micromolar range; however, isoaspartyl dipeptides are nonetheless the preferred substrates.