Home

Class 2 Family 2

Family 2 Overview

4 experimentally studied proteins

23 sequences in Swiss-Prot

3,107 unique sequences in UniRef100

Eukaryotic aspartylglucosaminidases

Clan 1: Family 1, Family 2, Family 3, Family 4, Family 5

Reference MonomerA

mono2-2.png

Reference Structure

1APY.png

Family 2 Motifs
(P20933)

motifs2-2

Experimentally Studied Proteins

Fam ? Class - Clan - Family Alt ? Alternative historical name / classification AN ? UniProt accession number Name ? UniProt entry name, only given here for Swiss-Prot entries EC Organism Cell-Loc AAs Structure PDB Km i for Asn [mM] Vmax i for Asn [μmol/min/mg] Kcat i for Asn [s-1]

Swiss-Prot Sequences

Fam ? Class - Clan - Family Alt ? Alternative historical name / classification AN ? UniProt accession number Name ? UniProt entry name, only given here for Swiss-Prot entries EC Organism Cell-Loc AAs Structure PDB Km i for Asn [mM] Vmax i for Asn [μmol/min/mg] Kcat i for Asn [s-1]

UniRef100 SequencesB

Download FASTA
Preparing download link...

Representative Sequence Alignment

Motifs Image

Additional Information

Clan 1 contains five families that are to an extent phylogenetically distinct from the other clans; they have aspartylglucosaminidase (AGA) activity in addition to l‑asparaginase activity.

Family 2 is well-studied and contains sequences of eukaryotic origin. One protein structure has been solved, the lysosomal Homo sapiens AGA (P20933); its Km for l‑asparagine is about four times higher than for aspartylglucosamines.