Class 1 Family 1

Family 1 Overview

5 experimentally studied proteins

9 sequences in Swiss-Prot

1,267 unique sequences in UniRef100

Mostly fungal l‑asparaginases

Saccharomyces cerevisiae high affinity isoenzymes

Clan 1: Family 1, Family 2, Family 3, Family 4

Reference Monomer^A

Reference Structure

Family 1 Motifs
(P0CX78)

Experimentally Studied Proteins

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]

Swiss-Prot Sequences

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]

UniRef100 Sequences^B

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Representative Sequence Alignment

Additional Information

Clan 1 holds 4 families and is somewhat analogous to the historical "type II" l‑asparaginases, as the families of this clan contain "type II" sequences, including the two in therapeutic use. It also has many cytoplasmic sequences and some of these were previously considered to be "type I" l‑asparaginases.

Family 1 contains mostly fungal l‑asparaginases, including the cytoplasmic Saccharomyces cerevisiae ScAI (P38986) and the allosteric cell wall Saccharomyces cerevisiae ScAII (P0CZ17) (several copies present in genome). Both enzymes show high affinity to l‑asparagine with a Km in the micromolar range.