0 experimentally studied proteins
0 sequences in Swiss-Prot
308 unique sequences in UniRef100
Putative L-asparaginases from bacteria and eukaryotes (algae, fungi, metazoans)
Diverse sequences with very poorly conserved motifs
Clan 3 is a small clan with only two families and no experimentally studied L-asparaginase. Many, not all, L-asparaginases in the clan show low sequence identity to any known L-asparaginases (~20% or lower).
Family 8 is remarkably diverse phylogenetically and structurally. It contains sequences from bacteria and eukaryotes, including algae, fungi, and some metazoans. Many have the preserved catalytic motifs of Class 1 L-asparaginases and show conservation of the L-asparaginase domain (up to ~0.85 TM-score to L-asparaginases with solved structures), but plenty are just fragments, lack the catalytic motifs or are part of a larger protein.
