Class 1 Family 2

Family 2 Overview

0 experimentally studied proteins

0 sequences in Swiss-Prot

1,694 unique sequences in UniRef100

Putative bacterial l‑asparaginases

Clan 1: Family 1, Family 2, Family 3, Family 4

Reference Monomer¹

Reference Structure

Family 2 Motifs
(A0A931LDC7)

Experimentally Studied Proteins

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]

Swiss-Prot Sequences

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]

UniRef100 Sequences²

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Representative Sequence Alignment

Additional Information

Clan 1 holds 4 families and is somewhat analogous to the historical "type II" l‑asparaginases, as the families of this clan contain "type II" sequences, including the two in therapeutical use. It also has many cytoplasmic sequences and some of these were previously considered to be "type I" l‑asparaginases.

¹Varadi, M et al. AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Research (2024). Licensed under CC BY 4.0.

²Suzek, B.E. et al. UniRef: comprehensive and non-redundant UniProt reference clusters. Bioinformatics (2007). Licensed under CC BY 4.0. Added classification code to sequence headers.